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Formulas

Where this leads

Part of The River — Heparin

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Here an organ is asked to make something; next, what it cannot make

One thread of this article has been left deliberately loose, and the next article picks it up.

Every formula here works by asking an organ to make something — heparin from the mast cells of liver and lung, something plasmin-like from the pancreas, prostaglandins, acetylcholine, calcium out of the bone. In each case the body already has the machinery and the raw material, and the treatment is a provocation to use them.

But some of the things a body runs on it cannot make at all, whatever it is asked. A vitamin is precisely a substance that has to come in from outside. And a therapist who has learned this article properly will now want to know what happens to a family of formulas when the thing the patient is short of is not being withheld by a sluggish gland but is genuinely absent — and what it can mean that a treatment named after a vitamin works at all. That is the whole subject of the next article, and it begins with a tired woman and her small son in Amritsar.

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